"Patch"ing up our tumor signaling knowledge.
نویسندگان
چکیده
The tumor suppressor Patched1 (Ptch1) possesses well-described roles in regulating sonic hedgehog (SHH) signaling in the skin and preventing the formation of basal cell carcinomas (BCCs). In this issue, Kang et al. extend their previous work to show that a naturally occurring allele of Ptch1 found in FVB mice promotes early squamous cell carcinoma (SCC) growth without aberrant activation of the SHH pathway. The study reveals new roles for Ptch1 that lie at the nexus between BCC and SCC formation.
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عنوان ژورنال:
- The Journal of investigative dermatology
دوره 133 5 شماره
صفحات -
تاریخ انتشار 2013